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Assessment of possible mutagenicity of betel leaf in saccharomyces cerevisiae

S.R. chughtai , akbar S. mohmand and B.A. siddiqi

Aqueous extract of betel leaf was tested for the induction of mitotic gene conversion, mitotic crossing over and reverse mutation in diploid strains of saccharomyces cerevisiae . tests performed with stationary and log phase cells showed that betel leaf extract was non-mutagenic in yeasts without metabolic activation . it failed to increase the frequency of convertants , recombinants and revertants. Betel leaf extract neither caused cell killing nor inhibition of cell divisions . EMS, used as control , exhibited mutagenic and recombinogenic activity.

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