PJB-2019-1038
PROTECTIVE EFFECT OF POTATO PEEL EXTRACTS AGAINST LEAD INDUCED HEPATO-RENAL TOXICITY IN MICE
Mubbashar Abbas
Abstract
This study was designed to evaluate hepatic and renal protective effect of potato peel extracts (PPE). Lead acetate at 40mg/kg/day to mice induced the generation of reactive oxygen species (ROS), lipid peroxidation, and antioxidant imbalance collectively called “oxidative stress”. The methanolic extract of potato peel at 100mg/kg/day reversed the lead acetate induced toxicity by restoring the fluctuation of aspartate transaminase (149.90 U/L), alanine transaminase (87.80 U/L), creatinine (1.15 mg/dl) and blood urea nitrogen (36.00 mg/dl). The potato peel extracts showed antioxidant property by encountering the lead acetate induced antioxidant imbalance by reversing catalase (19.10 µ/g), and malondealdehyde (249 nmol/g). Histopathologicaly, the inflammatory hepatocytes, infiltrated glomerulus and inflammatory renal tubules by lead acetate were alleviated by potato peel extracts. The methanolic extract exhibited more prominent protection than aqueous potato peel extract. This study concluded that potato peel extracts have protective potentianl against lead induced liver and kidney damage.
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