PJB-2019-819
PHYTOCHEMICALS OF THE BIOCTIVE FRACTIONS OF THE LEAVES OF SCAEVOLA TACCADA GAERTN.(ROXB)
Eman abdelGhani
Abstract
Scaevola taccada(Gaertn.) Roxb. is widely dispersed all along the coasts of Africa. Conventionally, different parts of S.taccada were useful for treatment of a diversity of ailments. In-vitro biological examination viz. antimicrobial, cytotoxic and antioxidant activities of the ethanol soluble of the leaves and its soluble fractions; in order of increasing polarity (petroleum ether, methylene chloride, ethyl acetate and n-butanol) were carried out. Estimation of the phytochemicals of biologically active fractions was through. n-butanol fraction displayed noteworthy antimycobacterium. Petroleum ether as well as n-butanol fractions evidenced a cytotoxic effect on MCF7 and HCT with IC50 11.7 and15.04 µgml-1 respectively. Moreover, ethyl acetate fraction exhibits an anti-oxidant effect with EC50 476.7 ± 0.57. Chromatographic analysis were afforded eight compounds which characterized as n-tetradecane1, α-amyrin palmitate2, α-amyrin acetate 3, α-amyrin 4, stigmasterol 5, luteolin-7-O-β-glucoside 6, rutin 7 and alidyjosioside 8. Fatty acid ester of α-amyrin, stigmasterol, rutin, luteolin-7-O-β-glucoside and alidyjosioside newely detected in Egyptian S.taccada leaves.
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