PJB-2019-684
QUANTIFICATION OF BIOCHEMICAL COMPOUNDS IN BAUHINIA VARIEGATA LINN FLOWER EXTRACT AND ITS HEPATOPROTECTIVE EFFECT
Hina Gul
Abstract
Liver disorders may occur as a result of exposure to chemical compounds capable of inducing oxidative stress and hepatic injuries. The aim of the present study was to investigate the effects of flower extracts of B. Variegata for the treatment of liver injury induced by the CCl4. About 1 ml/kg body weight (b.w) of CCl4 was induced to experimental mice by the intraperitoneal way for 14 days. The methanol and chloroform extracts (100, 200 and 300 mg/kg b.w) were administered to experimental animals for 14 days along with standard drug Silymarin (100 mg/kg b.w). The extracts alone showed no evidence of hepatic toxicity but animals exposed to CCl4 without the treatment with B. Variegatapresented variations in levels of liver enzymes, antioxidant enzymes, proteins, and blood cells as well as injuries in liver cells were also observed during the histopathological study. However, after the treatments especially with 300 mg/kg b.w of methanol flower extracts levels of liver markers (ALT, AST, and ALP), antioxidant enzymes and blood cells decreases and turned towards normal levels. Whereas the level of total proteins and bilirubin was improved and damaged liver cells were repaired. The curative activity of flower extracts can be correlated to the higher potential of antioxidants and occurrence of Quercetin and some other organic compounds that were investigated from flower extracts of B.Variegata during HPLC and GC-MS analysis. The finding of this study supports the use of B.Variegata flower formulation in folk medicines.
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