PJB-2019-565
CYTOTOXIC AND GENOTOXIC ACTIVITY OF TURKISH PALE LIVERWORT AGAINST HUMAN PERIFERAL BLOOD LYMPHOCYTES
Recep KARA
Abstract
Pale Lıverwort-Chiloscyphus polyanthos (L.) Corda is one of the most common aquatic liverworts that often grows in the river bank that remain submersed throughout the year. It typically formed extensive mats on the tops of boulders and elevated microsites on rock outcrops. In this study, Chiloscyphus polyanthos collected from the Erciyes Mountain were extracted using ethyl acetate, methanol and water –methanol solvents. Extracts were evaluated for their cytotoxic and genotoxic activities against human periferal blood lymphocyties. The genotoxic activity was determined by using the Chromosome Aberration test. Cytotoxic activities of the extracts were determined by Mitotic index (MI).Results demonstrated that the plant exract was found to have no genotoxic effect but there was cytotoxic effect on human peripheral blood lymphocytes.
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