PJB-2019-232
CHEMICAL CONSTITUENTS OF THE BIOCTIVE FRACTIONS OF THE LEAVES OF SCAEVOLA TACCADA GAERTN.(ROXB)
Abeer M.Elsayed
Abstract
Scaevola taccada(Gaertn.) Roxb. is widely dispersed all along the coasts of Africa. Conventionally, different parts of S.taccada were used for treatment of a variety of ailments. In-vitro biological examination viz. antimicrobial, cytotoxic and antioxidant activities of the ethanol extract of the leaves and its soluble fractions; petroleum ether, methylene chloride, ethyl acetate and n-butanol were carried out. Estimation of the phytochemicals of biologically active fractions was through. n-butanol fraction displayed noteworthy antimycobacterium. Petroleum ether as well as n-butanol fractions evidenced a cytotoxic effect on MCF7 and HCT with IC50 11.7 and15.04 µgml-1 respectively. Moreover, ethyl acetate fraction exhibits an anti-oxidant effect with EC50 476.7 ± 0.57. Chromatographic analysis were afforded eight compounds which characterized as n-tetradecane1, α-amyrin palmitate2, α-amyrin acetate 3, α-amyrin 4, stigmasterol 5, luteolin-7-O-β-glucoside 6, rutin 7 and alidyjosioside 8. Fatty acid ester of α-amyrin, stigmasterol, luteolin-7-O-β-glucoside, rutin and alidyjosioside newely detected in Egyptian S.taccada leaves.
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