PJB-2018-828
ANTIUROLITHIATIC EFFECT OF PERICAMPYLUS GLAUCUS ON ETHYLENE GLYCOL INDUCED UROLITHIASIS IN MALE RATS
MUHAMMAD KIFAYATULLAH
Abstract
Pericampylus glaucus is a common Malaysian plant used traditionally for remedies of urinary and kidney stones. Hence, present research was aimed to investigate the antiurolithiatic effect of ethanol extract of Pericampylus glaucus against ethylene glycol induced urolithiasis in rat. The nephrolithiasis was induced by ethylene glycol (0.75%) in drinking water for a period of 30 days. The animals were divided into normal, negative and extract treated group that received ethanolic extract of Pericampylus glaucus extract at dose of 200 and 400 mg/kg (b.wt) by mouth. The calcium, phosphate, urine pH, oxalate, magnesium in urine and histopathalogical examination of kidney were observed. A significant (p<0.01) increased in levels of phosphate, calcium, oxalate, an imbalance in the kidney with decreased magnesium excretion in urine was observed in ethylene glycol induced urolithiasis as compared to normal control. Treatment with ethanolic extract of Pericampylus glaucus at 200 and 400 mg/kg (b.wt) significantly (p<0.01) decreases hyperoxaluria, calcium, phosphate, oxalate with significant (p<0.05) increase retention of urinary magnesium and improvement in renal function as matched to lithiatic group. The histopathological examination indicates deposition of a large number of calcium oxalate crystal in lithiatic group while smaller depositions in 200 mg/kg (b.wt) extract treated group. The results confirmed the antiurolithiatic effect of Pericampylus glaucus in rat and validate its traditional uses against urinary stone.
To Cite this article:
Download
