PJB-2018-694
The Protective effect of Fenugreek Seeds Extract Supplementation on Glucose and Lipid Profile in Thioacetamide induced liver damage in rats
S.Nuzhat Fatima
Abstract
The intention of this study was to evaluate the hepatoprotective effect of Fenugreek seeds’ extract supplementation on Glucose and Lipid profile in thioacetamide induced liver damage in male Sprague Dawley rats. For this study, 24 male rats (200-264gm) were taken and divided into four groups. Group I serve as Control and remained untreated, group II received Thioacetamide 200mg/Kg b.w i.p. administered on alternative day for 8 weeks, group III received Thioacetamide 200mg/Kg b.w i.p. administered on alternative days for 8 weeks as well as 2ml of 2% extract of fenugreek seeds orally administered daily from 4th week till 8th week of the experiment. Group IV only received 2ml of 2% extract of Fenugreek seeds daily for 4 weeks respectively. At the end of the experiment, blood was collected; Plasma was used for Glucose and lipid profile analysis. Increased in Triglyceride, Cholesterol, LDL, VLDL and total lipid levels with a decreased in HDL and Glucose levels in TAA-treated group, which assured the liver damage. However, treatment with fenugreek seeds extract reduced the levels of Triglyceride, cholesterol, LDL, Total lipid with an increase in HDL and Glucose levels in Test+Supp rats (Group III). Treatment with Fenugreek seeds extract to rats of (group IV) lowered the lipid profile indicated that the supplement is hypolipidemic. The results of this study confirmed that treatment with Fenugreek seeds extract successively attenuates liver damage induced by Thioacetamide in male rats.
To Cite this article:
Download
