PJB-2017-584
ASSESMENT OF ANTICHOLINESTRASE ACTIVITY OF THREE LOCAL MEDICINAL PLANTS AND THEIR IMPLICATIONS AS POTENTAI THERAPEUTIC AGENT AGAINST ALZHEIMER�S DISEASE
Prof. Dr. Murad Ali Khan
Abstract
The use of complementary medicines, such as plant extracts, in dementia therapy varies according to the different cultural traditions. Various other plant species have shown favorable effects in Alzheimer�s disease, or pharmacological activities indicating the potential for use in Alzheimer�s disease therapy. Plants and their solvent based extract with pharmacological activities that may be relevant to the treatment of cognitive disorders, including enhancement of cholinergic function in the central nervous system, may be used as anti-cholinesterase inhibitor or anti-Alzheimer�s disease. As plants and their various solvents based extract have memory enhancement activities so in present study three plants were selected and their three solvent (n-hexane, ethyl acetate, chloroform) based extracts were prepared and evaluated for their anticholinesterase inhibitory activities by Ellman�s microplate method. The plants studied were Curcuma longa, Cinnnamomum tamala and Zingiber officinale, and they showed IC50 >200�g/ml. Considering the complex multifactorial etiology of Alzheimer�s disease, these plant extracts will be safer and better candidates for the future disease modifying therapies against this devastating disease.
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