PJB-2025-228
In vitro antibacterial activities of selected folk medicinal plants used for the treatment of Uropathogens in Pakistan
Huma Zareef
Abstract
Despite the presence of antibacterial agents for urinary tract infection treatment, most of the uropathogenic bacteria reveal multi-drug resistance. These bacteria result in health loss and a rising burden worldwide, necessitating serious action at regional, national and global levels. Medicinal plants are putative to overcome this problem. The in vitro antibacterial activity of methanol and ethanol crude extracts of Zingiber officinale, Trachyspermum ammi, Ricinus communis, Piper nigrum, Phyllanthus emblica and Nigella sativa was carried out using six dilutions (25, 50, 100, 125, 250 and 500) mg/ml in Agar well diffusion and macro broth dilution methods against Escherichia coli, Staphylococcus saprophyticus and Gardnerella vaginalis. The inhibition zone diameter produced by the methanol extract of each screened plant had higher inhibition zones than the ethanol extract. The highest inhibition zone was recorded for the ethanolic and methanolic crude extract of Nigella sativa seed against E.coli, Staphyloccus saprophyticus and Gardnerella vaginalis among tested plants. It was followed by Ricinus communis, while Trachyspermum ammi showed the lowest efficacy against tested bacteria. The crude extract of Nigella sativa seed and Ricinus communis fruit have promising antibacterial activity against tested uropathogenic bacteria. Furthur study is required to isolate compounds and their pharmacological activity.
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