PJB-2024-189
ESSENTIAL OILS EXTRACTION AND PHYTOCHEMICAL COMPONENTS IDENTIFICATION OF LAVANDULA ANGUSTIFOLIA MILL: UNVEILING THEIR POTENTIAL APTITUDE IN ANTIBACTERIAL RESPONSE AGAINST SELECTED STRAINS &
Dr. Bushra Arshad
Abstract
The occurrence and spread of antibiotic resistance is major perturbation globally and connected with inadequate availability and developments in new potent therapeutic agents. The screening of bioactive natural therapeutic components in quest for novel antibacterial agents has become essential to fight against antibacterial resistance. Essential oils of Lavandula angustifolia Miller (Lavender) are the pure, natural and organic extracts which are pretty well-known due to their conventional use in disease treatment. Hence, this study is planned to extract essential oils from leaves (L) and flowers (F) of Lavandula angustifolia Miller (lavender) cultivated in Nerian Sharif Azad Jammu and Kashmir (Pakistan) and further its subjection to unveil phytochemical components, and antibacterial properties. Hydro distillation is used to extract essential oils from leaves and flowers. After that, gas chromatography-mass spectrometry (GC-MS) analysis is used for identification of active compounds of essential oils. Antimicrobial activity of essential oils is evaluated using agar diffusion method and determined as a zone of inhibition. The main constituents are monoterpenes 70.05% (in F) and 61.58% (in L) followed by sesquiterpenes 5.75% (in F) and 4.28% (in L). Essential oils of lavender flowers and leaves exhibited good antibacterial activity against pathogenic selected strains (Escherichia coli, Salmonella typhimurium, Staphylococcus and Pseudomonas aeruginosa) at different dilutions. Results depicted that lavender essential oils (flowers and leaves) have pre-eminent antibacterial activity against Escherichia coli with zone of inhibition with standard deviation 28.8±0.6 & 25.9±0.4 respectively at 1:1dilution. It is concluded that lavender flowers and leaves essential oils have numerous potent phytochemicals, which have significant antimicrobial activity against listed microorganisms. Therefore, study suggested that Lavender essential oils might be a potent source to explore next generation antibiotics alone or in combinations with other agents in the future for the pharmaceutical industry.
To Cite this article:
Download
