PJB-2024-106
Effect of Aloe Vera on brain indoleamine 2, 3 dioxygenase activity and tissue antioxidant status in rats subjected to swim stress
Sobia Tahir
Abstract
ABSTRACT
Aleo barbedensis Mill commonly known as Aleo Vera (AV) from the family Asphodelaceae (Liliaceae) is a succulent plant with health benefits, which is reported to exhibit antioxidant , immunity boosting and antidepressant properties . Mood disorders such as depression can be caused due to impairment in brain neuronal activity due to changes in neurotransmitters. The Aloe vera plant has soothing and mood regulating properties .Inflammation plays a key role in the pathology of stress-related diseases. There are ample evidences that not only tryptophan (TRP) and consequent serotonin depletion, but also induction of indoleamine 2, 3-dioxygenase (IDO) by proinflammatory cytokines plays a role in the pathophysiology of depression. Present study aims to investigate the effects of AV on brain IDO activity, liver antioxidant status in rats subjected to swim stress. Adult Albino Wistar rats were divided into two groups (n=12 /group) control and AV-treated groups, Test group received an aqueous extract of AV orally at a dose of 0.2g/ml/kg-body-weight while control group received tap water for fourteen days. Behavioral analysis shows that AV possesses anxiolytic property in mice subjected to elevated plus maze test. A significant reduction in total locomotor activity/ exploratory behaviour in open field test. An antidepressant effects was shown by decreased (p<0.05) immobility time in forced swim test and a consequent decreases in brain IDO activity in AV treated rats. Moreover an antioxidant activity of AV was reflected in elevated CAT (p<0.01) and glutathione (GSH) (p<0.01) along with significant depletion in (MDA) (p<0.01) levels when compared to their respective controls. Taken together AV possesses a potent antioxidant and anxiolytic property and has the ability to mitigate stress induced depressive state by decreasing brain IDO activity thereby increasing tryptophan availability for central serotonin synthesis.
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