PJB-2024-39
THE NOVEL ANTIFUNGI OF ROSE MYRTLE FRUIT MICROWARE EXTRACT (RHODOMYRTUS TOMENTOSA) IN VITRO AND SILICO DOCKING STUDY IN CENTRAL VIET NAM
NGUYEN VAN HUE
Abstract
Myrtle fruit contains a large amount of phenolic compounds, which have been shown to have high biological activity with antioxidant, anti-cancer, and anti-obesity properties. The myrtle extract was evaluated for its antioxidant and antibacterial properties. The antioxidant activities of myrtle fruit extract were analyzed DPPH radical inhibition assay. The myrtle extract had an IC50 of 233.98 g.mL-1 and the antioxidant activity that was weaker than that of vitamin C. The gas chromatography–mass spectrometry (GC-MS) method with an HP5-MS column was used to analyze some biologically active compounds in myrtle extract. The myrtle extract contained 19 compounds, of which the names of only two compounds have been identified. It was noticeable that 2,3-dihydro-3,5-dihydroxy-6-methyl-4H-pyran-4-one was presented in myrtlee extract, a flavonoid compound that plays an important role in cancer prevention, cardiovascular disease prevention, and liver function protection. The novel anti fungi activity of rose myrtle fruit extract agianst Alternaria alternata apple pathotype indicated at concentrations of MIC of 25 mg.mL-1 are excellent activites. In silico docking model, pose 698/1000 or compound 12 docked well to 4AUD:PDB protein, and compound 12 or pose 505 inhibited well to 2VF5: PDB enzyme to expain general mechanism why compound 12 showed good activity in vitro. Microware equiment has apply to extract rose myrtle fruit extraction and indicated that the components of rose myrtle fruit extraction depend on the solvent polarity, ratio of solid and solvent, microware power, and time in microware treatment.
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