PJB-2023-1571
New insights for exploring the bioactive nature and biomedical activities of Allium cepa
Muhammad Naeem, Hira Iqbal, Muhammad Nadeem, Faiza Marrium, Hafiz Muhammad Khubaib, Safia Gul, Afroz Rais, Amer Jamil, Rana Khalid Iqbal and Tahani Awad Alahmadi
Abstract
Medicinal plants are a rich source of bioactive compounds and have been used for the treatment of infectious diseases. Allium cepa exhibited several pharmacological activities including antimicrobial, antioxidant, hemolytic, cytotoxic, and thrombolytic effects. However, a comprehensive understanding of its therapeutic properties is still lacking. Therefore, this study was conducted to investigate the medicinal significance and biological activities of Allium cepa. The extraction was carried out through fractions of methanol, ethanol, and distilled water. The antimicrobial activity was assessed through disc diffusion method, while antioxidant activity of extract was determined through DPPH free radical scavenging assay. Hemolytic activity was evaluated to assess the toxicity of onion extract, and thrombolytic activity was performed to examine its clot lysis potential. Our results revealed that methanolic extract of A. cepa showed high zone of inhibition (23.3 mm) than n-hexane (9.2 mm) against E. coli. Methanolic extract revealed high potential of DPPH free radical scavenging (40.6%) than n-hexane (23.3%). While on the other hand, methanolic extract showed high (10.1%) thrombolytic activity than distilled water (8.3%). N-hexane fraction showed higher hemolytic activity(45.4%) than distilled water (8.2%). The results demonstrated that the extract of Allium cepa exhibited antimicrobial, antioxidant, and thrombolytic potentials due to the presence of several antioxidants and flavonoids. This study could be used for discovering the novel bioactive compounds and also helpful for exploring the therapeutic applications of medicinal plants that could be used for biological target of emerging diseases
To Cite this article:
Naeem, M., H. Iqbal, M. Nadeem, F. Marrium, H.M. Khubaib, S. Gul, A. Rais, A. Jamil, R.K. Iqbal and T.A. Alahmadi. 2023. New insights for exploring the bioactive nature and biomedical activities of Allium cepa. Pak. J. Bot., 55(6): DOI: http://dx.doi.org/10.30848/PJB2023-6(23)
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