PJB-2023-110
PHYTOCHEMICAL DIVERSITY, CLASSIFICATION AND ANTIBACTERIAL ACTIVITY OF SOME MEDICINAL PLANT SPECIES FROM TABUK (SAUDI ARABIA)
Abdelrahim A. Elbalola
Abstract
The main objectives of this study were to investigate the intra-specific and inter-specific phytochemical diversity and classification of nine important medicinal plant species from Tabuk region (KSA, to evaluate the antibacterial potentials of the plant ethanolic extracts, and to inspect the possible associations between phytochemical diversity and contents of different phytochemical classes with the antibacterial activities of plant extracts. GC-MS technique was used to identify phytochemicals in the plant extracts. The standard disk diffusion technique was used to conduct the antibiotic susceptibility against four pathogenic bacterial species (two Gram positive: Staphylococcus aureus and Bacillus subtilis and two Gram negative species: Pseudomonas aeruginosa and Escherichia coli. A total of 160 different phytochemicals belonging to 30 compound classes were separated and identified. A. fragrantissima had the highest phytochemical diversity and P. incisa had the lowest one. Phytochemical beta diversity was 6.2362. Ethanolic extracts surpassed the antibiotic in antibacterial activity for 7 plant species. P. undulata extract exhibited the highest bacterial growth inhibition efficiency, while A. monosperma was the least efficient one. Gram positive bacterial species were more sensitive to plant extracts compared to Gram negative species. Phytochemical diversity and antibacterial activity of plant extracts were positively correlative, terpenoid and benzene & substituted derivative contents exhibited significant (p< 0.05) positive correlations with the antibacterial activity against E. coli.
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