PJB-2023-91
PHYTOCHEMICAL CHARACTERIZATIONS AND THERAPEUTIC SIGNIFICANCE OF CASSIA ABSUS LINN
ASMA BABAR
Abstract
Cassia absus Linn was selected because of its phytochemical importance and least exploration on local origin in Pakistan. It belongs to Fabeaceae family. The main focus of our study was to evaluate the biological significance of methanolic extract of seeds of Cassia absus (MECA) including antioxidant, antidiabetic and anti-inflammatory properties. Different phytochemical techniques, chromatography and spectroscopic analysis were employed on crude powder and MECA and found substantial amount of flavonoids, alkaloids, phenols tannins, saponins, carbohydrates, glycosides and terpenoids. The antioxidant potential of MECA was determined with various dilutions; 10, 20, 40, 80, 100 and 120 µg/ml and found expressively premier scavenging response using Phosphomolybdenum and DPPH protocols. Antidiabetic activity was assessed through α-amylase percentage inhibition protocol. The dose dependent substantial α-amylase suppression activity was perceived (35% - 87%) with dose range 0.1 – 0.7 mg/ml of MECA. The carrageenan induced paw edema model was implemented for evaluation of anti-inflammatory activity of MECA and significant control of inflammation was observed on comparison to control and reference (Diclofenac sodium). The experimental data proved that MECA extract has an appreciated therapeutic potential and this source may be play a pivotal role in various pharmaceutical formulations to manage diabetes, hypertension, gout and edematous conditions.
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