PJB-2022-378
PHYSICOCHEMICAL EVALUATION AND PHARMACOLOGICAL SCREENING OF FERNANDOA ADENOPYLLA (WALL.EX G. DON) STEENIS FRUITS
Arham Hassan
Abstract
Fernandoa adenophylla is well known for its’ numerous ethnomedicinal uses in Africa and south-east Asia. The current study was aimed to evaluate physicochemical properties, acute oral toxicity and some biological activates of fruits of Fernandoa adenophylla. In accordance with WHO guidelines, powder studies were carried out to estimate the quantitative physicochemical characteristics of the crude drug, including moisture content, ash content and extractive values. Using a Soxhlet apparatus and different analytical grade solvents, 3 sample extracts of crude drug (n-hexane, chloroform and ethanol) were made. To access the possible toxic nature of the plant, acute oral toxicity study was performed as per OECD guideline no. 423. All sample extracts were also tested for the presence of pharmacological potential (analgesic, antipyretic and antidiabetic) using Wister –Albino rats. Results were expressed as mean ± standard deviation and were analyzed by ANOVA. Where physicochemical analysis gave indications about purity, quality and presence of organic/inorganic materials in crude drug extracts, no sign of mortality was found up to 2000 mg/kg of body weight of F. adenophyllas extracts. Analgesic activity was observed in all sample extracts whereas, only chloroform and ethanolic extracts expressed antipyretic and antidiabetic potential. Ethanolic extract was found to be most potent in pharmacological potential as 200mg/kg extract dose exhibited %age pain inhibition of 55.12% and reduced body temperature from 39.78±0.03°C to 37.22±0.02°C in hyperthermic rats. A decrease in blood glucose levels up to 57.88% was observed at 21st day of the treatment with 500mg/kg ethanolic extract.
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