Paper Details

PJB-2022-355

Phytochemical screening, anti-diarrheal and antipyretic effects of methanolic extract of Ficus lyrata Leaves  

Rafia Andleeb
Abstract

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The leaf of Ficus.lyrata warb. (Moraceae) is used to treat GI disorder such as diarrhea in folklore use. The aim of present research is to explore the antidiarrheal and antipyretic activity of methanolic extract of leaves of F.lyrata. The antidiarrheal activity of methanolic extract of leaves of F.lyrata on castor oil induced diarrhea in rats weighing 150- 200 g. The anti-pyretic effects were also explored on yeast induced pyrexia. It also includes the physicochemical analysis of powder such as (total ash, water soluble ash, acid insoluble ash, moisture content, foaming index and swelling index) along with organoleptic evaluation of leaf of F.lyrata in order to access the quality or purity of substance. The phytochemical analysis of methanolic extract of F.lyrata leaves confirmed the presence of polyphenols, tannins, terpenoids, cardiac glycosides, flavonoids and reducing sugar. The antidiarrheal activity of MEFL at 250mg/kg and 500mg/kg body weight showed 62% and 76% reduction in defecation respectively. The decrease in intestinal fluid accumulation at same dose revealed 67.2% and 75% reduction in fluid accumulation in intestine of Wister albumin rats. The methanolic extract of F.lyrata showed reduction in distance travelled by charcoal meal such as 54% and 72% at dose 250 mg/kg and 500 mg/kg respectively. The antipyretic effect at a dose of 100 mg/kg and 200 mg/kg showed significant reduction in temperature. Phytochemical screening of F. lyrata revealed that methanolic extract of leaves contain flavonoids, glycosides, phenols, tannins, terpenoids, proteins and amino acid. The anti-diarrheal activity of the F. lyrata might be due to the presence of flavonoids.  

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