PJB-2022-344
INVESTIGATION OF BIOACTIVE COMPOUNDS AND THEIR BIOLOGICAL ACTIVITIES OF CAESALPINIA BONDUCELLA SEED EXTRACT
Yadala Keerthi Priya
Abstract
Caesalpinia bonducella belongs to the family Caesalpiniaceae. It has a broad range of pharmacological activities. Therefore, the present work was designed to study the antibacterial, antifungal and antioxidant activities of methanol extracts and compounds from Caesalpinia bonducella seeds. The phytochemical analysis revealed the presence of Phenols, Saponins, Anthroquiones, Lignins, Terpenoids, Triterpenes, Flavonoids, Amino acids, Carbohydrates, Alkaloids, Glycosides, Phytosterols, and Quinones. Further, the functional groups of these phyto-compounds were confirmed by Fourier-transform infrared spectroscopy. The methanol extract was identified with 19 compounds by Gas chromatography-mass spectrometer. Among them, the major 4 compounds have the highest peak area percent. They are Terpenoid-alfa-Copaene (17.9 %), Terpenoid-à-Muurolene (11.6 %), Fatty acid- n-Hexadecanoic acid (5.76 %), poly phenol -2-Propenoic acid, 3-(2-hydroxyphenyl)-, (E) - (4.26%) which are showing biological activity such as antibacterial, antifungal activity antioxidant and anti-inflammatory respectively. The methanol extract was tested against ten bacterial and three fungal strains. Among all the bacteria and fungi tested, the highest MIC was shown by P. aeruginosa with 21.39 mm and A. favus with 28.2 mm. The antioxidant activity of methanol extracts showed LOG IC50-1.330 and IC50 -21.39. Thus, the present study proved that methanol extract has significant potential activity hence it can be used as a functional ingredient in pharmaceuticals drug preparations.
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