PJB-2022-340
EVALUATION OF ANTI-CLOTTING AND THROMBOLYTIC POTENTIAL OF THE AQUEOUS-METHANOLIC EXTRACT OF JASMINUM SAMBAC
Gul-E-Mizgan
Abstract
Abstract
Objective: This study was done with aim to focus on the investigation of anti-clotting and thrombolytic potential of ariel part of Jasminum sambac. Healthy male rabbits were divided into 5 groups with each group containing 6 animals.
Methodology: Aqueous-methanolic extract of the plant was prepared and was given at different doses 200, 300 and 600mg/kg to three groups in comparison to negative and positive control groups. The aqueous-methanolic extract showed the (p<0.05) dose-dependent increase in the activated partial thromboplastin (APTT) and prothrombin time (PT), bleeding time (BT) and clotting time (CT). Warfarin 2mg/kg was used as standard.
Findings: The plant extract also showed significant (p<0.05) clot lysis in comparison with standard urokinase. Moreover, it also prolonged the ADP induced platelet adhesion 200, 300 and 600µg/mL dose dependently. HPLC analysis showed rutin, quercetin, salicylic acid and ascorbic acid as vital phytoconstituents in aqueous-methanolic extract.
Conclusion: Anticoagulant and thrombolytic effect of Jasminum sambac justified its therapeutic utility in cardiovascular disorders maybe due to salicylic acid, rutin and quercetin.
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