PJB-2021-751
PROSOPIS CINERARIA LEAVES: IN-VITRO PROCOAGULANT ACTIVITY OF ITS METHANOLIC EXTRACT
Ahmed Umer Sohaib
Abstract
Introduction: Prosopis cineraria (Pc) is a well-known tree in arid regions of Pakistan due to its medicinal and folkloric uses. Methodology: In this study, Methanolic Extract of Prosopis cineraria (MEPC) leaves were extracted by using methanol to evaluate possible platelet aggregation activity, calcium induced whole blood coagulation, fibrinolytic activity, prothrombin time (PT) and activated partial thromboplastin time (APTT). Platelet aggregation activity was determined in vitro by Platelet Rich Plasma (PRP), APTT and PT was measured in-vitro by Platelet Poor Plasma (PPP) and calcium induced whole blood coagulation and fibrinolytic activity was determined on non-citrated whole blood. Results and Discussion: The results showed that MEPC has significant platelet aggregation activity in a dose dependent manner when used alone. It has efficacy to induce coagulation in whole blood by successively increasing the dose. In platelet independent coagulation, by using thromboplastin and partial cephaloplastin, no definitive results were obtained by MEPC. Key words: Prosopis cineraria, platelet aggregation, blood coagulation
To Cite this article:
Download
