PJB-2021-719
A COMPREHENSIVE GENOMIC STUDY, MUTATION SCREENING, PHYLOGENETIC AND STATISTICAL ANALYSIS OF SARS-COV-2 AMONG DIFFERENT COUNTRIES
Syed Umair Ahmad
Abstract
With the rapid accumulation of SARS-CoV-2 genomic sequence information, there is an urgent requirement to accurately predict mutations within the genome. Presently, most vaccines and viral testing reagents are based on the genome sequence of the original viral isolate from Wuhan, China. Similarly, many studies are focused on spike protein for vaccines and drug development against SARS-CoV-2 as it is responsible for viral engagement to the host cell membrane and viral access into the cell. They are envisioned at stimulating the making of neutralizing antibodies that slab infection completely. However, this study aims to recognize real-time variations in the viral genome sequence among different countries to provide mutations snapshots and select potentially valid targets for vaccine designing. Furthermore, the present study endeavoured to construct a phylogenetic tree and detect the potential role of genomic mutations in the pathogenicity of SARS-CoV-2. This analysis included sequences of 157 strains of the SARS-COV-2 virus, full genome sequences from 20 countries. This quest index allows one to quickly identify and analyse the phase of evolution by aligning each other and creating a tree of each grouping. It helps to annotate and classify many similar sequences and can study variation between closely related cultivars and varieties as molecular markers. These results will enable understanding the form and type of completed genome, their derivatives, and their flowing genomic sequences and mutations in the various additions. The finding of this study can help to design the vaccine and to understand the genomic study of SARS-COV-2.
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