PJB-2020-251
Phytochemical screening and antispasmodic, analgesic, anti-inflammatory potentials of Ziziphus mauririana var. spontanea L. Edgew
ambrin
Abstract
The present research investigates phytochemical analysis and antispasmodic, analgesic, anti-inflammatory potentials of ethanolic samples of Ziziphus mauritiana var. Spontanea L. Edgew. Ethyl acetate and ethanolic extracts at 100, 200 and 300 mg/kg significantly (P<0.05) inhibited paw edema at 4th h and 5th h after injection. Ethyl acetate and ethanolic extract at 5th h showed significant anti-inflammatory activity where it caused 64.6%, 68.6% and70% and 57.3%, 60.6% and66.0% inhibition at 100, 200 and 300 mg/kg. The results of writhing method revealed that the ethanolic and ethyl acetate samples of Z. mauritiana revealed significant analgesic activity. At 200 and 300 mg/kg body weight dose, the ethanolic extract produced 25.0%, 72.6% (P<0.05) of writhing inhibition, greater than ethyl acetate extract and standard diclofenac sodium (68.5% inhibition). Hot plate method indicated that ethanolic and ethyl acetate extracts of Z. mauririana at (300mg/kg) significantly (p<0.05) increased basal reaction time after 90 min but lower than standard drug diclofenac which showed highest effect. The results of antispasmodic activity by charcoal meal test revealed that ethanolic and ethyl acetate samples of Z. mauritiana significantly inhibited charcoal movement at 300 mg/kg. Highest inhibition (18.6500±.21213) was shown by ethyl acetate at 300 mg/kg. The ethyl acetate extract showed comparatively higher inhibition than that of the standard drug atropine sulphate (20.600±.7000). Different extracts revealed various bioactive compounds.
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