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HYPOGLYCEMIC ACTIVITY OF HEDERA HELIX L. LEAVES AND THE POSSIBLE MECHANISM OF ACTION

MUHAMMAD IBRAR, IHSAN ILAHI* AND FARRUKH HUSSAIN*

Abstract: The present study showed that both the aqueous and methanolic extracts of Hedera helix L. were hypoglycemic, reducing the blood glucose level in both the normal and alloxan-induced diabetic rabbits to significant levels. Trace element analysis of the leaves showed that Hedera helix L. leaves contain the "hypoglycemic trace elements" (Chromium, Manganese & Zinc) in sufficiently large amounts and these have played the main role in reducing the blood glucose level.

Department of Pharmacy, University of Peshawar, Pakistan.
Department of Biotechnology, University of Peshawar, Pakistan.