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Pak. J. Bot., 47(SI): 313-319, 2015.

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ANTIMICROBIAL, PHYTOTOXIC, HEAMAGGLUTINATION, INSECTICIDAL

AND ANTIOXIDANT ACTIVITIES OF THE FRUITS OF

SARCOCOCCA SALIGNA (D. DON) MUEL.

BASHIR AHMAD¹, SAIMA NAZ¹, SADIQ AZAM^1*, IBRAR KHAN¹,

SHUMAILA BASHIR² AND FIDA HASSAN¹

¹Centre of Biotechnology and Microbiology, University of Peshawar, Khyber Pakhtunkhwa, Pakistan

²Department of Pharmacy, University of Peshawar, Khyber Pakhtunkhwa, Pakistan

*Corresponding author’s e-mail: azam_bbt@yahoo.com

Abstract: Crude methanol extract and different fractions of the fruits of Sarcococca saligna (D. Don) Muel were investigated for various pharmacological/biological activities; antibacterial, antifungal, phytotoxic, haemagglutination, insecticidal and antioxidant activities. The results revealed that the plant possess good antibacterial activity (65.3 and 63.0%) against Methicillin Susceptible Staphylococcus aureus (MSSA) and Salmonella typhi, respectively while rest of the fractions along with crude methanolic extract (Crd. MeOH Ext.) were found moderately active or inactive against the tested pathogens. Low antifungal activity was observed for A, D, H and J fractions while other test samples were found inactive against the test fungi. Moderate phytotoxic activity was shown by C, D, G, H, K and L fractions at higher concentration (1000µg/ml). Moderate insecticidal activity was shown by G, H and I fractions against T. castaneum and G, H, I, K and L against R. dominica. A concentration dependent Diphenyl Picryl Hydrazine (DPPH) free radical scavenging activity was shown by the test samples. Fruits of the plant lack phytolactines as no haemagglutination activity were observed against human erythrocytes.

Keywords: Antibacterial, Antifungal, Phytotoxic, Haemagglutination, Insecticidal, Antioxidant, Sarcococca saligna