PJB-2017-770
EVALUATION OF ANTI-PROLIFERATIVE, ANTIOXIDANT AND ANTI-INFLAMMATORY POTENTIALS OF CASSIA NEMOPHILA FLOWERS
Kiran Shahjeer
Abstract
Cancer is described as uncontrolled differentiation and proliferation of cells, effecting variety of normal body processes. It is multidimensional disease with multiple causes. Medicinal plants are valued for their significant potential of treating number of disorders. The study was planned to explore pharmacological properties of ethanolic and n-hexane extract of C. nemophila flowers. Cassia nemophila was selected for present study because of long history of genus Cassia in field of traditional and modern drug discovery, stipulated with active compounds. The contribution of extracts against oxidants was verified using DPPH radical scavenging assay. Anti-inflammatory activities were explored by HRBC membrane stabilization assay. While cytotoxic effects were investigated against viability of HCT115 cell line. The results implied the pharmacological importance of extracts of C. nemophila flowers and its effectiveness against antioxidant, anti-inflammatory and anti-proliferative activities. From current study, it can be concluded that C. nemophila flowers possess number of potential compounds due to which they can be used as an effective anticancer drug. Further research needs to be done in order to explore more properties of this plant species.
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