PJB-2017-502
EFFECT OF PHYTOCHEMICALS AS TRADITIONAL CHEMOTHERAPEUTIC AND CANCER PREVENTIVE AGENTS
Farah Abid
Abstract
Cancer has been designated worldwide as a second leading cause of death. The prognosis of cancer, despite concerted efforts in innovating and improving current cancer therapies, remains dismal. A limited or sporadic response has been associated with highly specific blockade of single signaling pathway. Thus, a new paradigm for anticancer therapy, that targets multiple signaling pathways, has emerged by using targeted therapies. Since centuries, secondary metabolites isolated from plants have been used in folk medicine for the treatment of diseases including cancer. Broadly, chemotherapeutic agents derived from plants are categorized into twelve major categories namely; alkaloids, phenylpropanoids, terpenoids, glycosides, aldehydes, lignans, lipids, unsaponified lipids, nucleic acids, polysaccharides, proteins and unidentified compounds. This review provides detailed mechanism by which some of the notable plants, possessing anti-tumor properties, exert their effect.
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