Paper Details

Abstract

Diabetes mellitus is a major global health concern, particularly in developing countries. In this study, six multigrain formulations (F1-F6) comprising barley (Hordeum vulgare L.), buckwheat (Fagopyrum esculentum Moench), faba bean (Vicia faba L.) and mulberry (Morus alba L.) were developed and evaluated for antidiabetic potential using diabetic induced albino rats. Prior to biological evaluation, proximate composition analysis was conducted for all formulations, revealing significant variations among nutritional parameters. Ash content ranged from 2.44 to 2.84%, with the highest value in F4. Moisture content varied between 6.72% and 9.16%. Protein levels increased across formulations, reaching a maximum of 11.15% in F6. Fiber content ranged from 9.66 to 11.15%, while fat remained low in all samples (1.16–2.24%). Mineral analysis revealed the highest iron content in F6 (120.67 mg/100 g) and maximum zinc in F1 (28.38 mg/100 g). Carbohydrates ranged from 66.83 to 72.72%. In vivo evaluation of six-multigrain formulations against diabetic induced albino rats demonstrated promising antidiabetic effects across all treatments. Initial diabetic levels (IDL) were comparable among groups, indicating uniform induction of diabetes. A progressive reduction in blood glucose levels was observed over 14 days for all formulations. Among them, F4 exhibited the most pronounced hypoglycemic effect, showing the lowest glucose level at day one to day 14 (402 to 107 mg/dL), followed by F2 (400 to 112.67 mg/dL) and F6 (415 to 124.67 mg/dL). Based on the low glycemic levels, F4 emerged as the most effective formulation, suggesting its superior antidiabetic potential among the tested multigrain diets. Based on these findings, it is strongly suggested that diabetic-affected communities adopt the regular consumption of multigrain-based foods, as they offer a natural, effective and sustainable dietary approach to improve glycemic control and combat diabetes

To Cite This Article