PJB-2026-65
BEHAVIORAL EFFECTS FOLLOWING CHRONIC ADMINISTRATION OF CHAMOMILE EXTRACT IN MALE ALBINO WISTAR RATS
Iqra Sheikh
Abstract
Matricariachamomilla L. is globally recognized and well-studied medicinal plants, known for its therapeutic impact on the cerebrospinal axis. The current research explored the neurobehavioral effects of chronic chamomile consumoption in male albino rats.The study utilized eighteen rats and split into two groups, with nine rats allocated each.Saline has been given to control group n in other treated group administered orally with Hydroalcoholic extract of Chamomile dose of 300 mg/kg for three weeks . Behavioral assessments were conducted to evaluate anxiety related actions, depression-like symptom, motor activity, and learning and memory. The anxiety like behavior was assessed with the help of paradigm elevated plus maze, locomotor activity using the open field apparatus, depression-like behavior using the forced swimming test, and to measure spatial learning and memory,morris water test has been used. The results indicated that chronic chamomile administration had no significant effect on anxiety-like behavior, as treated rats did not exhibit more exploration of the open arms in the elevated plus maze compared to controls. Locomotor activity was reduced, as evidenced by fewer square crossings in the open field test. In contrast, chamomile treatment significantly reduced depression-like behavior via a reduction of time of mobility in the forced swimming test. Surprisingly, the rats with chamomile had a longer escape latency in the Morris water maze, which means that they had poor learning and memory performance. Such results indicate that although chronic chamomile intake might have antidepressant like and weak sedative effects, it makes no major decrease in anxiety and can have adverse effects of cognitive functioning, which could be explained by its soothing or relaxing effects. The neurochemical mechanisms underlying these effects of behaviors need further research.
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