For millennia, numerousdiseases have been effectively cured by medicinal plants. It might be of interest to establish what diseases these plants may cure. In this research, three critical plants, namely Fagonia indica, Berberis vulgaris, and Trachyspermum ammi were investigated for the presence of heavy metals (HMs) and macronutrient. Heavy metals are abundant in the soil, water, food, herbal drugs, milk, plants, fish, and microfluidic. The presence of HMs across difference environments possess advantages and disadvantages. However, some HMs of broad ranges are non-toxic for humans, and these include zinc, iron, manganese, and copper which have advantages in human health. Others (state some examples) exert toxic effects at relatively low concentration in soft tissues of the body. Inhalation of lead-based paints raises the risk of toxic effects of HMs, as does consumption of food and medicine from a contaminated container. Exposure to pollution in water, air and industry emissions also increases the risk of poisonous effects of HMs. Common signs and symptoms rendered by heavy metal consumption include weakness, chills, vomiting, dyspnea, nausea, memory loss, diarrhea and tingling in feet and hand. Macronutrients have significant roles in human health. In order to find the HM and macronutrient molecules various sections of the plants and their nutritive content were extensively studied. The important macro-nutrients include oxygen, hydrogen, carbon, potassium, phosphorus, nitrogen, sulfur, calcium, and magnesium.