PJB-2025-404
PHYTOCHEMICAL CHARACTERIZATION AND IN VITRO ANTIHYPERTENSIVE EVALUATION OF QUISQUALIS INDICA L. LEAF EXTRACTS
Farah Rana
Abstract
Medicinal plants have long been used for the treatment of different diseases or to mitigate symptoms. In developing countries, almost 80% of the population is dependent on the traditional medicine system, because of affordability issues with high cost of modern medicine. This study aims to evaluate the leaves of Quisqualis indica L.for their antihypertensive potential through comprehensive phytochemical, physicochemical, and pharmacological analysis. Authenticated plant material was subjected to hot (Soxhlet) and cold maceration extraction using solvents of varying polarity. Extracts were evaluated for proximate composition, ash and extractive values, and moisture content following WHO and USP (2005) standards. Phytochemical screening confirmed the presence of carbohydrates, proteins, lipids, flavonoids, phenolics, glycosaponins, and polysaccharides assessed in different organic solvents of varying polarities. The results indicate that analytical profiling via in vitro inhibition assay through UV–Visible and FTIR spectroscopy shows verified characteristic absorption peaks of various phytoconstituents like phenolic compounds, flavonoids, and alkaloids. The methanolic extract exhibited the highest ACE inhibitory activity (78.87%), closely comparable to the standard drug captopril (79.3%), these findings scientifically validate the traditional use of Q. indica in cardiovascular diseases and suggest its potential as a natural, safe, and effective source of antihypertensive agents.
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