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Abstract

A Current study was done to evaluate the maximum therapeutic potential of methanol and distilled water stem extracts of C. tuberculata on the basis of polarity, on a series of in vitro biological and antioxidant assays (i.e., Phytochemical analysis, total phenol flavonoid and tannin contents, 2,2-Diphenyl-1- picryl hydrazyl (DPPH) assay and alpha-amylase inhibition assay). The Methanolic extract has maximum potential and revealed a higher number of compounds similarly, showed a high % inhibition of alpha-amylase activity 99.12 % rather than distilled water stem extract which is 65.55 % and plant extracts exhibited a higher IC₅₀ value of 759.35 µg/ml with minimal inhibitory activity as compared standard 25.60 µg/ml. The comparative efficacy of the anti-diabetic potential of the C. tuberculata revealed good results. The activity pattern observed in this study was Methanol > Acarbose > Distilled water. DPPH free radicals can be easily scavenged by C. tuberculata stem extracts at concentrations of 50, 100, 125, 250, and 500 µg/mL. It has been concluded that C. tuberculata stem extracts are beneficial against diabetes and have possessed anti-oxidant activity as well. The extracts of C. tuberculata stem have a broad spectrum of anti-diabetic and anti-oxidant activity and support the traditional use of this plant as medicine.

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