PJB-2023-182
PHARMACOLOGICAL EVALUATION AND HPLC ANALYSIS OF CALLIGONUM POLYGONOIDES FROM THE CHOLISTAN DESERT
Fatima Sadiq
Abstract
Due to the high cost and adverse side effects of allopathic drugs, the use of medicinal plants for the treatment of various illnesses has tremendously increased. In the current investigation stem, root, and flower of C. polygonoides were used to make Aqueous (Aq), MtOH, EtOAc, EtOH, and n-hexane extracts. Qualitative phytochemical analysis has revealed the presence of carbohydrates, proteins, glycosides, and other phytochemicals. HPLC PDA analysis revealed the presence of different phenolic compounds in significant quantities. In antibacterial activity, EtOAc extracts of stem and root whereas EtOH extract of the flower was most effective though all the other extracts were positive in varying order. In the antibiofilm assay, EtOH extract of stem and root whereas multiple extracts of the flower have shown high antibiofilm potential. Antioxidant potentials observed by DPPH assay revealed that MtOH extract of the stem, EtOH extract of roots, and EtOH extract of flowers showed max scavenging potential. Similarly, in FRAP assay the EtOAc extract of the stem, MtOH extract of root, and n-hexane extract of the flower have shown the highest antioxidant potentials. In α-glucosidase inhibition assay, Aq extracts of stem and root have shown max activity, whereas, all extracts of flowers have shown excellent inhibition potential. According to antiviral activity, Aq extracts of different parts were most active against AIVH9N2 whereas, in the case of IBV different extracts were active in varying order. It can be positively stated that C. polygonoides possesses great pharmacological importance and is a rich source of various biologically active compounds
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