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Pak. J. Bot., 44(3): 1103-1109, 2012.

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SELECTED MEDICINAL PLANTS USED IN HERBAL INDUSTRIES; THEIR TOXICITY AGAINST PATHOGENIC MICROORAGANISMS

HINA FAZAL^1,3*, NISAR AHMAD², BILAL HAIDER ABBASI² AND NAAZ ABBASS⁴

Abstract: Multi-drug resistant strains of fungi and bacteria are imposing the need for new drugs. Reliable natural sources with minor side effects are needed to control anti-human pathogenic invaders specially bacteria. Given the demands for natural products that are inherently safe and environmentally compatible, the advancement in antimicrobial potential has provided a better alternative to synthetic resistance antibiotics. In the present investigation such types of medicinal plants were selected for analyses that are used by local herbal practioners for multiple diseases. Thirty three extracts of Achillea millefolium, Acorus calamus, Arnebia nobilis, Fumaria indica, Gymnema sylvestre, Origanum vulgare, Paeonia emodi, Peganum harmala, Psoralea corylifolia, Rauwolfia serpentina and Vetiveria zizanioides in chloroform, ethanol and hexane were investigated for their antimicrobial potential. These extracts were tested against eight microorganisms including four gram negative bacterial strains viz., Escherichia coli, Pseudomonas aeruginosa, Klebsiella pneumoniae and Salmonella typhi, three gram positive bacterial strains Staphylococcus aureus, Bacillus subtilis and Bacillus cereus and a fungal strain viz., Candida albicans. Majority of the extracts showed marked antimicrobial potential against the tested microorganisms.

¹Department of Plant Sciences, Quaid-i-Azam University, Islamabad 45320 Pakistan

²Department of Biotechnology, Quaid-i-Azam University, Islamabad 45320 Pakistan

³Pakistan Council of Scientific and Industrial Research (PCSIR) Laboratories Complex, Peshawar 25100, Pakistan

⁴Pakistan Council of Scientific and Industrial Research (PCSIR) Laboratories Complex, Lahore, Pakistan

*Corresponding author E-mail: hina_fazalso@yahoo.com